Publications

46. Costi S, Morris LS, Kirkwood KA, Hoch M, Corniquel M, Vo-Le B, Iqbal T, Chadha N, Pizzagalli DA,  Whitton AE,  Bevilacqua L,  Jha MK, Ursu S, Swann AC,  Collins KA, Salas R, Bagiella E, Parides MK, Stern ER, Iosifescu DV,  Han M-H, Mathew SJ, Murrough JW. Impact of the KCNQ2/3 channel opener ezogabine on reward circuit activity and clinical symptoms in depression: results from a randomized controlled trial. American Journal of Psychiatry. 2021 Mar 3 [ePub ahead of print]. Published article

45. Kumar P, Jiang S, Whitton AE. Brain imaging of reward dysfunction in unipolar and bipolar disorders. In: Selvaraj S, Brambilla P, Soares JC (Eds.) Mood Disorders: Brain Imaging and Therapeutic Implications. UK: Cambridge University Press; 2021, pp.39-48. Published chapter

44. Whitton AE, Kumar P, Treadway MT, Rutherford AV, Ironside ML, Foti D, Fitzmaurice G, Du F, Pizzagalli DA. Mapping disease course across the mood disorder spectrum through a Research Domain Criteria (RDoC) framework. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. 2021 Jan 26 [Epub ahead of print]. Published article

43. Parker BL, Chackouch C, Subotic-Kerry M, Batterham P, Mackinnon A, Newby JM, Whitton AE, McGoldrick J, Cockayne N, O’Dea B. A cluster randomised controlled trial of the Building Educators’ Skills in Adolescent Mental Health (BEAM) training program: Trial protocol. JMIR Research Protocols. 2021 Feb 24;10:e25870. Published article

42. Shaw SR, El-Omar H, Roquet D, Hodges JR, Piguet O, Ahmed RM, Whitton AE, Irish M. Adopting a transdiagnostic approach to determine the the prevalence and neural substrates of anhedonia in frontotemporal dementia. Brain. [Accepted 30 Nov 2020].

41. Whitton AE, Merchant, J, Lewandowski, KE. Dissociable mechanisms underpinning effort-cost decision-making across the psychosis spectrum. Schizophrenia Research. 2020 Oct 9;224-133-140. Published articleFree full text article

40. Reilly EE, Whitton AE, Pizzagalli DA, Rutherford AV, Stein MB, Paulus MP, Taylor CT. Diagnostic and dimensional evaluation of implicit reward learning in social anxiety disorder and major depression. Depression & Anxiety. 2020 Sep 9;37:1221-1230. Published article

39. Pizzagalli DA, Smoski M, Ang Y-S, Whitton AE, Sanacora G, Mathew SJ, Nurnberger J Jr, Lisanby SH, Iosifescu DV, Murrough JW, Yang H, Weiner RD, Calabrese JR, Goodman W, Potter WZ, Krystal AD. Selective kappa opioid antagonism ameliorates anhedonic behavior: Evidence from the Fast-Fail Trial in mood and anxiety spectrum disorders (FAST-MAS). Neuropsychopharmacology. 2020 Jun 16;45:1656–1663. Published article

38. Murphy M, Whitton AE, Deccy S, Ironside ML, Rutherford A, Beltzer M, Sacchet M, Pizzagalli DA. Abnormalities in electroencephalographic microstates are state and trait markers of major depressive disorder. Neuropsychopharmacology. 2020 Jun 26;45:2030-2037. Published article

37. Carpenter JS, Iorfino F, Cross SPM, Nichles A, Zmicerevska N, Hoyos Lopez V, Groot J, Crouse JJ, Palmer J, Whitton AE, White D, Naismith SL, Guastella A, Hermens DF, Scott J, Scott EM, Hickie IB. Protocol for the Brain and Mind Centre Optymise Cohort: Tracking multi-dimensional outcomes in young people presenting for mental health care. BMJ Open. 2020 Mar 1;10: e030985. Published article

36. Krystal AD, Pizzagalli DA, Smoski M, Mathew SJ, Nurnberger J Jr, Lisanby SH, Iosifescu D, Murrough JW, Yang H, Weiner RD, Calabrese JR, Sanacora G, Hermes G, Keefe RSE, Song A, Goodman W, Szabo ST, Whitton AE, Gao K,  Potter WZ. Application of the “Fast-Fail” approach to evaluating the potential of selective Kappa Opioid Antagonism as a treatment for anhedonia: A randomized proof of mechanism trial assessing effects on the ventral striatum. Nature Medicine. 2020 Mar 30;26:760-768. Published article

35. Whitton AE, Reinen JM, Slifstein M, Ang Y-S, McGrath PJ, Iosifescu DV, Abi-Dargham A, Pizzagalli DA, Schneier FR. Baseline reward processing and ventrostriatal dopamine function are associated with pramipexole response in depression. Brain. 2020 Feb 10;143:701-710. Published article; Free full text article

34. Whitton AE, Webb CA, Dillon DG, Kayser J, Rutherford A, Goer F, Fava M, McGrath P, Weissman M, Parsey R, Adams P, Trombello JM, Cooper C, Deldin P, Oquendo MA, McInnis MG, Carmody T, Bruder G, Trivedi MH,  Pizzagalli DA. Pre-treatment rostral anterior cingulate cortex connectivity with salience network predicts depression recovery: Findings from the EMBARC randomized clinical trial. Biological Psychiatry. 2019 May 15;85:872-880. Published article

33. Whitton AE, Treadway MT, Ironside ML, Pizzagalli DA. Neurobiological Reward-Related Abnormalities Across Mood Disorders. In: The Oxford Handbook of Positive Emotion and Psychopathology 2019 (pp. 223-238). Oxford University Press. Published chapter

32. Whitton AE, Lewandowski KE. Reward processing and social functioning in psychosis. In: Social Cognition in Psychosis 2019 (pp. 177-200). Academic Press. Published chapter

31. Finan PH, Whitton AE, Letzen JE, Remeniuk B, Robinson ML, Irwin MR, Pizzagalli DA, Smith MT. Experimental sleep disruption and reward learning: moderating role of positive affect responses. Sleep. 2019 May 1;42:zsz026. Published article

30. Sperl MFJ, Panitz C, Rosso IM, Dillon DG, Kumar P, Hermann A, Whitton AE, Hermann C, Pizzagalli DA, Mueller EM. Fear extinction recall modulates human frontomedial theta and amygdala activity. Cerebral Cortex. 2019 Feb 1;29:701-715. Published article

29. Whitton AE, Green AI, Pizzagalli DA, Roth RM, Williams JM, Brunette MF. Potent dopamine D2 antagonists block the reward-enhancing effects of nicotine in smokers with schizophrenia. Schizophrenia Bulletin. 2019 Oct 24;45:1300-1308. Published article

28. Kaiser RH, Treadway MT*, Wooten DW*, Kumar P*, Goer F, Murray L, Beltzer M, Pechtel P, Whitton AE, Cohen AL, Alpert NM, El Fakhri G, Normandin MD, Pizzagalli DA. Frontostriatal and dopamine markers of individual differences in reinforcement learning: A multi-modal investigation. Cerebral Cortex. 2018 Dec 1;28:4281-4290. *These authors made equal contributions. Published article

27. Tan A, Costi S, Lorris LS, Van Dam NT, Kautz M, Friedman AK, Collins KA, Ahle G, Chadha N, Whitton AE, Dunsky K, Do B, Pizzagalli DA, Iosifescu DV, Nestler EJ, Han M-H, Murrough JW. Effects of the KCNQ channel opener ezogabine on functional connectivity of the ventral striatum and clinical symptoms in patients with major depressive disorder. Molecular Psychiatry. 2018 Nov 1; 25:1323-1333. Published article

26. Pizzagalli DA, Whitton AE, Webb CA. Mood disorders. In: APA handbook of psychopathology: Psychopathology: Understanding, assessing, and treating adult mental disorders, Vol. 1 2018 (pp. 403-427). American Psychological Association. Published article

25. Schneier FR, Slifstein M, Whitton AE, Pizzagalli DA, Reinen J, McGrath PJ, Iosifescu DV, Abi-Dargham A. Dopamine release in antidepressant-naïve major depressive disorder: a multimodal [11C]-(+)-PHNO positron emission tomography and functional magnetic resonance imaging study. Biological Psychiatry. 2018 May 25;84:563-573. Published article

24. Whitton AE, Mehta M, Ironside ML, Murry G, Pizzagalli DA. Evidence for diurnal variation in implicit reward learning. Chronobiology International. 2018 Apr 24;35:1104-1114. Published article

23. Whitton AE, Deccy S, Ironside ML, Kumar P, Beltzer P, Pizzagalli DA. EEG source functional connectivity reveals abnormal high-frequency communication among large-scale functional networks in depression. Biological Psychiatry: Cognitive Neuroscience & Neuroimaging. 2017 Jul 12;3:50-58. Published article

22. Nangle MR, Bailey PE, Henry JD, Khlentzos GS, Varcin KJ, Whitton AE. Age invariance in rapid facial affective reactions to emotionally valenced stimuli. Quarterly Journal of Experimental Psychology. 2017 June 18;71:1687-1698. Published article

21. Whitton AE, Van’t Veer A, Kakani P, Dillon DG, Haile A, Crowley DJ, Pizzagalli DA. Acute stress impairs frontocingulate activation during error-monitoring in remitted depression. Psychoneuroendocrinology. 2017 Jan 31;75:164-174. Published article

20. Lewandowski LE, Whitton AE, Pizzagalli DA, Norris L, Ongur D, Hall MH. Reward learning, neurocognition, social cognition, and symptomatology in psychosis. Frontiers in Psychiatry. 2016 Jun 14;7:a100. Published article

19. Clarke J, Proudfoot J, Whitton AE, Birch M-R, Boyd MA, Parker G, Manicavasagar V, Fogarty A. Therapeutic alliance with a mobile phone and web intervention for depression, anxiety and stress: Secondary analysis of a randomized controlled trial using mixed methods. JMIR Mental Health. 2016 Jan 1;3:e10. Published article

18. Whitton AE, Kakani P, Foti D, Van’t Veer A, Haile A, Crowley DJ, Pizzagalli DA.  Blunted neural responses to reward in remitted major depression: A high-density event-related potential study. Biological Psychiatry: Cognitive Neuroscience & Neuroimaging, 2016 Jan 31;1:87-95. Published article

17. Peechatka AL, Whitton AE, Farmer SL, Pizzagalli DA, Janes AC. Cigarette craving is associated with blunted reward processing in nicotine-dependent smokers. Drug & Alcohol Dependence. 2015 Oct 1;155:202-207. Published article

16. Janes AC, Pedrelli P, Whitton AE, Pechtel P, Douglas S, Martinson M, Huz I, Fava M, Pizzagalli DA, Evins AE. Reward responsiveness varies by smoking status in women with a history of major depressive disorder. Neuropsychopharmacology. 2015 Jul 1;40;1940-1946. Published article

15. Whitton AE, Treadway MT, Pizzagalli DA. Reward processing dysfunction in major depression, bipolar disorder and schizophrenia. Current Opinion in Psychiatry. 2015 Jan 1;28:7-12. Published article

14. Whitton AE, Proudfoot J, Clarke J, Birch M-R, Parker G, Manicavasagar V, Harrison V, Hadzi-Pavlovic D. Breaking open the black box: Isolating the most potent components of a web and mobile phone-based intervention for depression, anxiety and stress. JMIR Mental Health. 2015 Jan 1;2.1:e3. Published article

13. Whitton AE, Henry JD, Grisham JR. Cognitive and psychophysiological correlates of disgust in obsessive-compulsive disorder. British Journal of Clinical Psychology. 2015 Mar 1;54:16-33. Published article

12. Clarke J, Proudfoot J, Birch M-R, Whitton AE, Parker G, Manicavasagar V, Harrison V, Christensen H, Hadzi-Pavlovic D. Effects of mental health self-efficacy on outcomes of a mobile phone and web intervention for mild-to-moderate depression, anxiety and stress: Secondary analysis of a randomized controlled trial. BMC Psychiatry. 2014 Sep 26;14:272. Published article

11. Grisham JR, Becker L, Williams AJ, Whitton AE, Makkar S. Using cognitive bias modification to deflate responsibility bias in compulsive checkers. Cognitive Therapy and Research. 2014 Oct 1;38:505-517. Published article

10. Proudfoot J, Whitton AE, Parker G, Manicavasagar V, Nicholas J, Smith M. Evidence of a weekly cyclicity in mood and functional impairment in individuals with a bipolar disorder. Psychiatry Research. 2014 Aug 30;218:290-294. Published article

9. Whitton AE, Henry JD, Rendell PG, Grisham JR. Disgust, but not anger provocation, enhances levator labii superioris activity during exposure to moral transgressions. Biological Psychology. 2014 Feb 28;96:48-56. Published article

8. Whitton AE, Henry JD, Grisham JR. Moral rigidity in obsessive-compulsive disorder: Do abnormalities in inhibitory control, cognitive flexibility and disgust play a role? Journal of Behavior Therapy and Experimental Psychiatry. 2014 Mar 1;45:152-159. Published article

7. Proudfoot J, Clarke J, Birch M-R, Whitton AE, Parker G, Manicavasagar V, Harrison V, Christensen H, Hadzi-Pavlovic D.  Impact of a mobile phone and web psychological program on depression, anxiety, stress, work and social functioning: A randomized controlled trial. BMC Psychiatry. 2013 Nov 18;13:312. Published article

6. Whitton AE, Grisham JR, Henry JD, Palada HD. Interpretive bias modification for disgust. Journal of Experimental Psychopathology. 2013 Jul 21;4:341-359. Published article

5. Whitton AE, Henry JD. The relationship between sub-clinical obsessive-compulsive symptoms and social cognition in chronic schizophrenia.  British Journal of Clinical Psychology. 2013 June 1;52:155-128. Published article

4. Proudfoot J, Jayawant A, Whitton AE, Parker G, Manicavasagar V, Smith M., Nicholas J.  Mechanisms underpinning effective peer support: A qualitative analysis of interactions between expert peers and patients newly diagnosed with bipolar disorder. BMC Psychiatry. 2012 Nov 9;12:192. Published article

3. Proudfoot J, Whitton AE, Parker G, Doran J, Manicavasagar V, Delmas K.  Triggers of mania and depression in young people with bipolar disorder.  Journal of Affective Disorders. 2012 Dec 20;143:196-202. Published article

2. Proudfoot J, Parker G, Manicavasagar V, Hadzi-Pavlovic D, Whitton AE, Nicholas J, Smith M. Effects of adjunctive peer support on perceptions of illness control and understanding in an online psychoeducation program for bipolar disorder: A randomized controlled trial.  Journal of Affective Disorders. 2012 Dec 15;142:98-105. Published article

1. Proudfoot J, Parker G, Hadzi-Pavlovic D, Manicavasagar V, Adler E, Whitton AE.  Community attitudes to the appropriation of mobile phones for monitoring and managing depression, anxiety and stress.  Journal of Medical Internet Research. 2010 Dec 19;12:e64. Published article